Membership of the Royal Colleges of Physicians (MRCP) Practice Exam 2025 - Free MRCP Practice Questions and Study Guide

In a patient with a long history of ulcerative colitis, the most likely cause of abnormal liver function tests is primary sclerosing cholangitis (PSC). This condition is a progressive cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, which is frequently associated with inflammatory bowel diseases, particularly ulcerative colitis. PSC leads to the eventual obstruction of bile flow, causing liver dysfunction and abnormal liver function tests.

The association between PSC and ulcerative colitis is well-documented, with a significant percentage of patients with PSC having underlying inflammatory bowel disease. The liver function tests typically show cholestatic patterns, which include elevated alkaline phosphatase and gamma-glutamyl transferase levels, indicative of bile duct involvement.

Understanding the relationship between ulcerative colitis and PSC can help clinicians identify patients at risk for liver complications, enabling earlier monitoring and management of hepatic involvement. Other causes of abnormal liver function tests, while relevant in different contexts, do not have the same strong association with ulcerative colitis as primary sclerosing cholangitis does.